How much weight can you lose a week on Wegovy (semaglutide)?

The amount of weight per week one loses on Wegovy® will vary from one patient to the next. Importantly, Wegovy is used in combination with lifestyle changes such as a reduced calorie diet and increased physical activity to promote weight loss. In this study, people lost on average about 6% of their starting weight by 12 weeks, about 10% by 20 weeks, and about 15% by one year (a little more than 0.5 lb per week). Importantly, when starting a Wegovy prescription, patients begin at the lowest dose (0.25 mg weekly) and gradually increase every four weeks to a maximum dose of 2.4 mg weekly as long as the medication is well tolerated. For some patients, weight loss may not start until they reach a higher dose of the medication.